Identification of exercise-related genes in mice exposed to cigarette smoke

ABSTRACT: Cigarette smoke (CS) is the major risk factor for COPD and is linked to cardiopulmonary dysfunction. Exercise training, as part of pulmonary rehabilitation, is recommended for all COPD patients. It has several physiological benefits, but the involved mechanisms remain poorly defined. Here, we employed transcriptomic profiling and examined lung endothelium to investigate novel interactions between exercise and CS on cardiopulmonary alterations. Mice were exposed to 20 weeks of CS, CS + 6 weeks of high-intensity interval training on a treadmill or control. Lung and cardiac (left and right ventricle) tissue were harvested, and RNA-sequencing was performed and validated with RT-qPCR. Immunohistochemistry assessed pulmonary arteriolar changes. Transcriptome analysis between groups revealed 37 s

INSTRUMENT(S): Illumina HiSeq 4000, Illumina

ORGANISM(S): Mus musculus

SUBMITTER:  

PROVIDER: E-MTAB-12256 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP141538

REPOSITORIES: biostudies-arrayexpress