Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

ScRNA-seq of PBMCs from stable ITP patients before TPO-RA discontinuation. STOPAGO study.

ABSTRACT: The STOPAGO study enrolled adults with persistent or chronic primary immune thrombocytopenia (ITP) and complete response to thrombopoietin receptor agonist (TPO-RA). TPO-RA discontinuation was planned in the study and patients with sustained complete response off-treatment (SCROT, platelet count > 100 G/L and no bleeding) and non sustained response (NSR, platelet count < 30 G/L or bleeding) were identified at week 24. RNAseq of peripheral blood mononuclear cells was performed at baseline, before TPO-RA discontinuation. Samples originated from 8 patients (4 with SCROT and 4 with NSR). The objectif was to identify putative markers that would predict relapses after TPO-RA discontinuation by comparing SCROT and NSR patients.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Etienne Crickx

PROVIDER: E-MTAB-12397 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dataset Information

ScRNA-seq of PBMCs from stable ITP patients before TPO-RA discontinuation. STOPAGO study.

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