ATAC-Seq analysis of LYN deficient HS-5 stroma cells

ABSTRACT: LYN kinase is a tyrosine kinase, that regulates cellular homeostasis in a context-specific manner. Our group could show, that its expression in the leukemic microenvironment of chronic lymphocytic leukemia contributes to disease progression (Nguyen PH et al.; Cancer Cell; 2016). To analyze the effect of LYN kinase on the leukemia supportive phenotype of the bone marrow stromal cell line HS-5, we generated single cell clones of LYN deficient stroma cells. These cells were analyzed in a Multi-Omic approach, including ATAC-Seq analysis of adapted epigenetic regulations.

INSTRUMENT(S): 454 GS FLX

ORGANISM(S): Homo sapiens

SUBMITTER: Ali Abdallah 

PROVIDER: E-MTAB-12531 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress