Host transcriptome profiling of the Lumpy Skin Disease (LSD) for resilience and susceptibility

ABSTRACT: Lumpy Skin Disease (LSD) is an endemic viral infection in Africa, newly emerging in Europe and becoming a global threat. There is host variation in response to infections in field studies and under carefully controlled artificial infections. It’s sometimes around 50% in clinical trials. This study aims to understand the mechanisms underlying this diversity and find the determinants to distinguish between susceptible (recovered) and resistant (non-recovered) animals through Differential Gene Expression (DGE) analysis. Five approximately 6-month-old male Holstein bulls were experimentally infected with LSDV. RNA sequencing was done for whole blood samples collected five days prior (pre-infection) to 3, 7, and 15 days after the infection (post-infection) challenge. After the challenge, two an

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Bos taurus

SUBMITTER: Mohammad Hossein Banabazi 

PROVIDER: E-MTAB-12547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress