Genotyping by array of genomic variation in seven Khoe-San groups to reveal adaptation and complex African history

ABSTRACT: The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped ~2.3 million SNPs in 220 southern Africans and found that the Khoe-San diverged from other populations at least 100,000 years ago, but structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa, instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response, potential adaptive introgression of UV-light protection, and selection predating modern human diversification involving skeletal and neurological development. These new findings illustrate the i

ORGANISM(S): Homo sapiens

SUBMITTER: Carina Schlebusch 

PROVIDER: E-MTAB-1259 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress