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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Impact of inducing hypercholesterolemia on Kupffer cells

ABSTRACT: Kupffer cells (KCs) are the largest tissue resident macrophage population in direct contact with blood and thus with circulating lipoproteins. How KCs homeostasis is affected by the build-up of cholesterol-rich lipoproteins in the context of hypercholesterolemia has been poorly investigated. In this study, 5-month-old LDL receptor deficient (C57BL6J background) male mice were subjected to chow diet or a cholesterol-rich (HC) diet for four days to induce hypercholesterolemia. RNA sequencing was then performed on cell sorted KCs.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Dussaud sebastien

PROVIDER: E-MTAB-12611 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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