Blood and urine multi-omics analysis of the impact of e-vaping, smoking and cessation – from exposome to molecular responses

ABSTRACT: Cigarette smoking is a major cause of preventable morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for smokers who would otherwise continue to smoke. A key challenge for the clinical assessment of NCAs is that self-reported product use can be unreliable, compromising the proper evaluation of their risk reduction potential. In this cross-sectional study with 205 healthy volunteers, we combined comprehensive exposure characterization with in-depth multi-omics profiling to compare effects across four study groups: cigarette smokers (CS), e-vapor users (EV), former smokers (FS) and never smokers (NS). Multi-omics analyses included metabolomics, transc

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-MTAB-12751 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress