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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of Paneth cells and whole ileum from human Crohn's disease patient ileo-colic resection tissue

ABSTRACT: Transcriptional profiling of microscopically laser dissected Paneth cells and whole thickness ileum tissue from the proximal margins of archived formalin-fixed, paraffin-embedded ileo-colic resection samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Kelli VanDussen

PROVIDER: E-MTAB-1281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease.

VanDussen Kelli L KL Liu Ta-Chiang TC Li Dalin D Towfic Fadi F Modiano Nir N Winter Rachel R Haritunians Talin T Taylor Kent D KD Dhall Deepti D Targan Stephan R SR Xavier Ramnik J RJ McGovern Dermot P B DP Stappenbeck Thaddeus S TS

Gastroenterology 20130925 1

<h4>Background & aims</h4>Genetic susceptibility loci for Crohn's disease (CD) are numerous, complex, and likely interact with undefined components of the environment. It has been a challenge to link the effects of particular loci to phenotypes of cells associated with pathogenesis of CD, such as Paneth cells. We investigated whether specific phenotypes of Paneth cells associated with particular genetic susceptibility loci can be used to define specific subtypes of CD.<h4>Methods</h4>We performe ...[more]

PMID: 24076061

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