Single Cell Analysis in trisomic tissues and organoids

ABSTRACT: Cortical organoids generated from mESC from a Down Syndrome (DS) mouse model (Ts65Dn) were dissociated for single cell sequencing to understand whether differential gene expression in DS brains affects cell diversity and how the molecular events that control the development of these diverse types of neocortical neurons are affected by the trisomy. These results were generated in parallel to a single cell experiment in forebrain fetal tissue from WT and Ts65Dn mice.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Cesar Sierra 

PROVIDER: E-MTAB-12827 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress