DNA sensing and Interferon Beta 1 transactivation drive radiation-induced anti-tumor immune effects in human pancreatic cancer cells

ABSTRACT: We demonstrate that a clinically relevant X-ray hypofractionation regimen (3x8 Gy) of multiple PDAC cel lines effectively induces immunogenic cell death and transactivates Interferon beta-1 in a STING-dependent manner. RNA-seq analyses showed a global and steady upregulation of type I interferon response in PDAC cells following 3x8 Gy.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Vedran Franke 

PROVIDER: E-MTAB-13096 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress