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RUVBL1 and RUVBL2 as novel druggable DNA Damage Response regulators in the MYCN regulatory network in neuroblastoma

ABSTRACT: To understand its role RUVBL1/2 in neuroblastoma, we inhibited RUVBL1/2 ATPase activity two independent cell lines, SK-N-AS and CBL-BA, with 250 nM CB-6644 at 0, 24, 48, and 72 hrs and performed RNA sequencing.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Joachim Siaw

PROVIDER: E-MTAB-13137 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma

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