Transcriptional response of Saccharomyces cerevisiae to the proapoptotic unsaturated fatty aldehyde t-2-hexadecenal by RNAseq

ABSTRACT: Hexadecenal, a trans (-2,3-) unsaturated fatty aldehyde, is an intermediate of the sphingolipid degradation pathway. This pathway, induced during cellular stress, involves the conversion of sphingosine-1-phosphate to hexadecenal by Sphingosine-1-Phosphate-Lyase (SPL) in humans and DPL1 in yeast. Hexadecenal is further metabolized to hexadecenoic acid by Fatty Aldehyde Dehydrogenase (ALDH3A2 in humans and HFD1 in yeast). Trans-2-hexadecenal (t-2-hex), has been found to induce mitochondrial dysfunction in a conserved manner from yeast to humans. However, the specific mechanisms and biological targets underlying this lipid-induced mitochondrial inhibition remain largely unknown. In this study, we employed unbiased transcriptomic approaches using the Saccharomyces cerevisiae yeast model to el

INSTRUMENT(S): DNBSEQ-G400

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Josep Fita-Torró 

PROVIDER: E-MTAB-13188 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress