ScRNA-seq analysis demonstrate alterations in TICs of the TME during TREM1 inhibition and anti-PD-1 treatment in B16F10 melanoma

ABSTRACT: To comprehensively characterize the changes within the TME during TREM1 deficiency and anti-PD-1 immune checkpoint blockade therapy, we performed scRNA-seq analysis of the CD45+ TICs in melanoma-bearing C57BL/6 mice receiving the various treatments. We analyzed approximately 8,249 CD45+ cells from the treatment groups with t-SNE analysis, identifying 10 distinct clusters of tumor-infiltrating immune cells

INSTRUMENT(S): Octo MACS Dissociator, NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Ashwin Ajith 

PROVIDER: E-MTAB-13300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress