RNA-Seq Analysis of Human Lung Cancer Cell Line A549 Following GSE1 Knockdown: Differential Gene Expression and Pathway Analysis Against siRNA Controls

ABSTRACT: The A549 cell line is often used as a model for human lung adenocarcinoma, and thus, insights gained from studies using these cells can be valuable for understanding lung cancer biology. The gene of interest, GSE1, may play a crucial role in regulating various cellular functions. By knocking down GSE1 and observing the transcriptomic changes, the study aims to identify the downstream effects and pathways regulated by this gene. These could include pathways critical for cell growth, apoptosis, or other essential cellular functions. This can lead to better understanding of the role of GSE1 in lung cancer and may even identify potential therapeutic targets. The primary objectives of the experiment are: 1. To effectively knock down the expression of the GSE1 gene in A549 cells. 2. To perform a

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Yixuan Chen 

PROVIDER: E-MTAB-13316 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress