LncRNAs at 13q14.3
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maiwen Caudron-Herger
PROVIDER: E-MTAB-1335 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.
Garding Angela A Bhattacharya Nupur N Claus Rainer R Ruppel Melanie M Tschuch Cordula C Filarsky Katharina K Idler Irina I Zucknick Manuela M Caudron-Herger Maïwen M Oakes Christopher C Fleig Verena V Keklikoglou Ioanna I Allegra Danilo D Serra Leticia L Thakurela Sudhir S Tiwari Vijay V Weichenhan Dieter D Benner Axel A Radlwimmer Bernhard B Zentgraf Hanswalter H Wiemann Stefan S Rippe Karsten K Plass Christoph C Döhner Hartmut H Lichter Peter P Stilgenbauer Stephan S Mertens Daniel D
PLoS genetics 20130404 4
Non-coding RNAs are much more common than previously thought. However, for the vast majority of non-coding RNAs, the cellular function remains enigmatic. The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL). While no point mutations have been found in the protein coding candidate genes at 13q14.3, they are deregulated in mal ...[more]
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