Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Concetta Faniello
PROVIDER: E-MTAB-1336 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Misaggi Roberta R Di Sanzo Maddalena M Cosentino Carlo C Bond Heather M HM Scumaci Domenica D Romeo Francesco F Stellato Claudia C Giurato Giorgio G Weisz Alessandro A Quaresima Barbara B Barni Tullio T Amato Francesco F Viglietto Giuseppe G Morrone Giovanni G Cuda Giovanni G Faniello Maria Concetta MC Costanzo Francesco F
Gene 20131114 2
Ferritin is best known as the key molecule in intracellular iron storage, and is involved in several metabolic processes such as cell proliferation, differentiation and neoplastic transformation. We have recently demonstrated that the shRNA silencing of the ferritin heavy subunit (FHC) in a melanoma cell line is accompanied by a consistent modification of gene expression pattern leading to a reduced potential in terms of proliferation, invasiveness, and adhesion ability of the silenced cells. In ...[more]