Multi-tissue transcriptome analysis for the identification of candidate genes associated with weight regulation in Hanwoo cattle

ABSTRACT: While genetic markers related to meat production traits have been identified in many other breeds of cattle, research on weight in Hanwoo cattle (Korean native cattle) has been relatively limited. In this study, we performed expression quantitative trait loci (eQTL) analysis and differential gene expression analysis to detect candidate genes influencing the weight characteristics of 32 castrated Hanwoo cattle across 22 tissues and identify variants that affect gene expression levels. In total, we identified a total of 2,465 differentially expressed genes, among which we discovered key genes such as UBD, RGS2, FASN, and SCD that have functions related to adipogenesis, body weight, obesity, and lipid metabolism. Gene-set enrichment analysis revealed that candidate genes in adipose tissue are

INSTRUMENT(S): Illumina NovaSeq 6000, -

ORGANISM(S): Bos taurus

SUBMITTER: Subin Jang 

PROVIDER: E-MTAB-13398 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress