RNAseq of organ-cultured human hair follicles exposed to MEKi (Cobimetinib)

ABSTRACT: EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of hair follicle immune privilege and differential modulation of IL-33 and IL-37 expression. Our findings suggest that successful future management of EGFRi/MEKi-induced folliculitis requires restoration of hair follicle immune privilege. In this RNAseq organ-cultured human hair follicles were directly exposed to MEKi (Cobimetinib) or the control DMSO (n=5 patients (6-8 hair follicles per patient)).

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Rachel Scholey 

PROVIDER: E-MTAB-13454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress