Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of 700 responsive mutants out of 1,484 budding yeast deletion mutants

ABSTRACT: This dataset consists of 700 responsive mutants (four or more significant mRNA expression changes as a result of the deletion) from a gene expression profile compendium of 1,484 deletion mutants that have a role or are implicated in mRNA transcription regulation, mRNA turnover, signaling or are located in the nucleus.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Patrick Kemmeren 

PROVIDER: E-MTAB-1383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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To understand regulatory systems, it would be useful to uniformly determine how different components contribute to the expression of all other genes. We therefore monitored mRNA expression genome-wide, for individual deletions of one-quarter of yeast genes, focusing on (putative) regulators. The resulting genetic perturbation signatures reflect many different properties. These include the architecture of protein complexes and pathways, identification of expression changes compatible with viabili  ...[more]

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