MRNA sequencing of rat hearts treated chronically with rofecoxib or its vehicle

ABSTRACT: We reported previously that chronic treatment with the Cyclooxygenase-2 inhibitor, rofecoxib, increased acute mortality in rats exposed to ischemia/reperfusion injury (I/R). This manifestation of hidden cardiotoxicity was attributed to the proarrhythmic effect of the drug on the ischemic heart. However, rofecoxib also had beneficial effects on ischemic injury, manifesting as decreased infarct size. In the present study, we aimed to identify molecular changes caused by chronic rofecoxib treatment in the heart. Rats were treated with 5.12 mg/kg rofecoxib or its vehicle for four weeks. Messenger RNA (mRNA), microRNA (miRNA) deep sequencing data, and proteomic datasets of left ventricular tissue samples were used for an unbiased differential expression analysis followed by in silico molecular

INSTRUMENT(S): NextSeq 550

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bennet Weber 

PROVIDER: E-MTAB-13913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress