Dataset Information
Illumina Expression Array Data for 21 Adenoid Cystic Carcinoma samples also subjected to whole exome sequencing
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stuart McLaren
PROVIDER: E-MTAB-1397 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Whole exome sequencing of adenoid cystic carcinoma.
The Journal of clinical investigation 20130617 7
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further delineate the genetics of the disease. We identified multiple mutated genes that, comb ...[more]
