ChIP-seq investigating the influence of astrocytes on the epigenetic landscape of developing cortical neurons

ABSTRACT: Astrocytes are implicated in neuronal development, particularly excitatory synaptogenesis, but their genome-wide impact is unclear. Using cell-type specific ChIP-seq we show that cortical astrocytes induce widespread changes in developing cortical neurons in histone marks associated with active open chromatin and repressed/condensed chromatin. Rat cortical neurons were maintained in the presence or absence of mouse astrocytes, ChIP-seq performed, and mixed-species ChIP-seq reads sorted according to species.

INSTRUMENT(S): NextSeq 550

ORGANISM(S): Rattus norvegicus

SUBMITTER: Owen Dando 

PROVIDER: E-MTAB-14081 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress