The Barrett’s precursor state to oesophageal adenocarcinoma shares features with transient cell populations in the developing human oesophagus - snRNA-seq

ABSTRACT: In the precursor pathology for oesophageal adenocarcinoma, Barrett’s oesophagus (BO), the adult stratified squamous epithelium is replaced by a simple columnar phenotype. This has been considered metaplasia; the inappropriate conversion from one adult cell-type to another. In fact, BO could be a reversal of mammalian embryogenesis when the early foregut is first lined by simple columnar epithelium. Exploring this hypothesis has been hampered by inadequate molecular details of human oesophageal development. Here, we adopted single cell transcriptomic and epigenomic approaches to discover and decode the cell types that constitute the initial primitive columnar, transitory and subsequently stratified lower oesophageal epithelium. Each stage is comprised of several previously undefined epithel

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Syed Murtuza Baker 

PROVIDER: E-MTAB-14127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress