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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of LSC-like and Mature populations from human AML patient samples

ABSTRACT: Acute myeloid leukemia (AML) is a highly heterogeneous disease consisting of different cell states that drive therapy resistance. We aimed to transcriptionally characterize AML subpopulations from patients treated with standard chemotherapy or BCL-2 inhibitor Venetoclax. We used CD64 and CD11b expression to define Mature blasts and labelled the rest as Immature. We used GPR56 expression to further enrich for LSC-like cells within the Immature cells. We performed RNA sequencing on 169 FACS-sorted LSC-like (GPR56+) and 111 Mature (CD64+CD11b+) cells.

INSTRUMENT(S): NextSeq 550

ORGANISM(S): Homo sapiens

SUBMITTER: Aino-Maija Leppä

PROVIDER: E-MTAB-14142 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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