Single-nuclei sequencing of mouse brain tissue and single-cell sequencing of FACS-sorted mouse astrocytes, investigating the effect of absence of microglia in the developing brain

ABSTRACT: Microglia, brain-resident macrophages, have been proposed to play an active role in synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Using a genetically modified mouse which lacks microglia (Csf1r ∆FIRE/∆FIRE), we investigate the effect on gene expression in particular cell types of the presence or absence of microglia in the developing mouse brain.

INSTRUMENT(S): NextSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Owen Dando 

PROVIDER: E-MTAB-14160 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress