Evaluation of a non-animal toolbox informed by adverse outcome pathways (AOPs) for human inhalation safety

ABSTRACT: Concentration- and time- response and human lower EpiAveolar™ respiratory tract tissues comparison of transcriptional responses following 12-day exposure with different test materials. Differential expression and pathway analyses were performed to estimate the lowest transcriptional point of departure (PoD) - minimum effect concentration when a biological perturbation as estimated by gene expression changes could be identified.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Renato de-Avila 

PROVIDER: E-MTAB-14272 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress