Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

57 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRCE expression

ABSTRACT: We have created a global map of the effects of polymorphism on gene expression in 550 children from families recruited through a proband with atopic dermatitis. We genotyped >300,000 SNPs and identified expression quantitative trait loci from measurements of 16,487 probes representing 15,576 genes in Epstein-Barr virus¨Ctransformed lymphoblastoid cell lines. We executed genome-wide association scans for these traits.

ORGANISM(S): Homo sapiens

SUBMITTER: Liming Liang

PROVIDER: E-MTAB-1428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

MRCA expression

Project description:We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epstein-Barr virusﾡﾧCtransformed lymphoblastoid cell lines. We executed genome-wide association scans for these traits.

2013-01-09 | E-MTAB-1425 | biostudies-arrayexpress

E-PROT-145

Project description:Atopic dermatitis epidermis PCT-DIA

2024-06-05 | E-PROT-145 | ExpressionAtlas

E-GEOD-16161

Project description:Broad defects in epidermal cornification in atopic dermatitis (AD) identified through genomic analysis

2025-01-24 | E-GEOD-16161 | ExpressionAtlas

Genomic profiling of the overlap phenotype between psoriasis and atopic dermatitis

Project description:Clinical overlaps between psoriasis and atopic dermatitis are sometimes undiscernible, and there is no consensus whether to treat the overlap phenotype as psoriasis or atopic dermatitis. We enrolled patients diagnosed with either psoriasis or atopic dermatitis, and clinically re-stratified them into classic psoriasis, classic atopic dermatitis, and the overlap phenotype between psoriasis and atopic dermatitis. We compared gene expression profiles of lesional and nonlesional skin biopsy tissues between the three comparison groups. Global mRNA expression and T-cell subset cytokine expression in the skin of the overlap phenotype were consistent with the profiles of psoriasis and different from the profiles of atopic dermatitis. Unsupervised k-means clustering indicated that the best number of distinct clusters for the total population of the three comparison groups was two, and the two clusters of psoriasis and atopic dermatitis were differentiated by gene expression. Our study suggests that clinical overlap phenotype between psoriasis and atopic dermatitis has dominant molecular features of psoriasis, and genomic biomarkers can differentiate psoriasis and atopic dermatitis at molecular levels in patients with a spectrum of psoriasis and atopic dermatitis.

2023-06-24 | GSE182740 | GEO

E-GEOD-36842

Project description:Transcription profiling by array of acute and chronic atopic dermatitis compared to normal skin

2025-01-24 | E-GEOD-36842 | ExpressionAtlas

Metagenome sequencing of feces of mouse treated D-galactose or not

Project description:D-galactose orally intake ameliorate DNCB-induced atopic dermatitis by modulating microbiota composition and quorum sensing. The increased abundance of bacteroidetes and decreased abundance of firmicutes was confirmed. By D-galactose treatment, Bacteroides population was increased and prevotella, ruminococcus was decreased which is related to atopic dermatitis.

2022-04-29 | E-MTAB-11632 | biostudies-arrayexpress

EGR1 increases the innervation density of epidermal sensory neurons via upregulation of ARTN in keratinocytes in atopic dermatitis

Project description:Atopic dermatitis (AD) is the chronic inflammatory skin disease accompanied with severe pruritus. To explore the roles of EGR1 in atopic dermatitis and the relationship between EGR1 and pruritus-scratching behavior, we used a atopic dermatitis-like mouse model driven by house dust mite (HDM) treatment in wild type and EGR1 KO mice, followed with RNA-sequencing analysis.

2024-01-15 | GSE214750 | GEO

E-GEOD-58558

Project description:Transcription profiling of skin samples from atopic dermatitis patients before and after treatment with cyclosporine A

2025-01-24 | E-GEOD-58558 | ExpressionAtlas

Microarray transcriptome profiling of atopic dermatitis and psoriasis patients compared to healthy volunteers.

Project description:Characteization host-microbiome interactions in patients with allergic (model: atopic dermatitis) and autoimmune (model: psoriasis) diseases by integration of microarray transcriptome data with 16S microbial profiling. 6mm punch biopsies were collected from the skin of atopic dermatitis and psoriasis patients alongside healthy volunteers, and subjected to analysis using Affymetrix Human Gene ST 2.1 arrays.

2019-09-11 | E-MTAB-8149 | biostudies-arrayexpress

Potential Functionality of Cutibacterium acnes Extracellular Vesicles in Atopic Dermatitis and Acne Vulgaris: A Comparative Proteomic Analysis

Project description:Comparative analysis of Cutibacterium acnes extracellular vesicles proteomics from atopic dermatitis and acne vulgaris.

2023-06-03 | PXD042715 |