IGR_MEGACARYOCYTES_STUDY_OB

ABSTRACT: The molecular bases of cellular changes that occur during ontogeny of human megakaryopoiesis remained unknown. We performed global gene expression profiling of pure populations of megakaryocytes (MK) derived from ES cells (MKES), fetal liver (MKFL), cord blood (MKCB) and adult blood (MKAD). A close pair-wise relationship between MKES and MKFL and between MKCB and MKAD was detected, respectively. A modest number of genes (695) was found differentially regulated along development. Major changes occurred in genes encoding cytoskeleton, platelet membrane and a-granule proteins, suggesting a functional MK maturation during development. MK ontogeny-associated changes in the expression of cell cycle regulators (e.g. AURKA, AURKB, PLK1) may account for the progressive increase in cell ploidy obser

ORGANISM(S): Homo sapiens

SUBMITTER: Philippe DESSEN 

PROVIDER: E-MTAB-1452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress