RNA-seq of human liver cancer cell line SNU-398 treated with a novel sulfane sulfur donor (PSCP) against untreated controls

ABSTRACT: This study elucidates the molecular mechanisms underlying the antitumor effects of a novel sulfane sulfur donor compound on hepatocellular carcinoma (HCC) cells using RNA sequencing analysis. While sulfane sulfur has emerged as a crucial signaling molecule with therapeutic potential in cancer treatment, its precise mechanisms of action remain to be fully elucidated. We synthesized a novel sulfane sulfur donor (persulfided cysteine precursor, PSCP) that exhibits potent inhibitory effects on HCC cells. Through comprehensive RNA-seq analysis of PSCP-treated HCC cells versus controls, we uncovered a complex regulatory mechanism involving mitochondrial damage, AMPK activation, and p53-mediated cellular responses, including both proliferation inhibition and apoptosis induction. Our findings demo

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-MTAB-14578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress