Single-Cell Roadmap of Early Hemato-Endothelial Development: Roles of Atf3, Zfp711, And Bcl6b

ABSTRACT: Hematopoiesis in embryonic and adult life is the process of producing blood cells. In mammalian embryos, hematopoiesis occurs in three consecutive overlapping waves (Neo et al. 2021; Dzierzak and Bigas 2018) and is regulated by transcription factors (TFs) and signaling molecules. In this study, we investigated the function of three relatively poorly studied TFs in early embryonic hematopoietic development at single-cell resolution: Activating transcription factor 3 (Atf3), Zinc finger protein 711 (Zfp711), and B cell CLL/lymphoma 6, member B (Bcl6b) respectively. We observed that these three TFs are upregulated early in development when hematopoietic and endothelial lineages separate from cardiac and other mesodermal lineages. To study the roles of these TFs in a rapidly changing system wi

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Ridvan Cetin 

PROVIDER: E-MTAB-14678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress