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ScRNA-seq of healthy human PBMC samples treated with recombinant AAV8 or controls, assessed at multiple time-points

ABSTRACT: The study investigates the interaction between rAAV and the innate immune system. We conducted single cell RNA-sequencing (scRNA-seq) of PBMCs from six healthy human donors, comparing samples taken either before or after 1, 4 or 24 hrs of incubation with rAAV8. As a control, scRNA-seq was performed on untreated whole blood incubated under the same culture conditions to consider the potential impact of the ex vivo culture on the blood cells.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Petra Catalina Schwalie

PROVIDER: E-MTAB-14760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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