Multi-Tissue WGBS Analysis in Mini Pigs: Body Size and Tissue-Specific Comparisons

ABSTRACT: This study utilized methylome data to comprehensively analyze the epigenetic landscape across five tissues (heart, liver, kidney, back fat, and loin) of minipigs. As the demand for organ transplantation continues to rise, xenotransplantation has gained significant attention as a promising solution to address the critical shortage of organ donors. Minipigs are considered a highly promising animal model for xenotransplantation research due to their remarkable physiological and anatomical similarities to humans. To evaluate the potential of minipigs, this study identified tissue-specific methylation patterns and differentially methylated regions (DMRs) related to body size, offering an in-depth exploration of their epigenetic characteristics. The findings revealed that tissue-specific methyla

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Sus scrofa

SUBMITTER: Seongjun Kim 

PROVIDER: E-MTAB-14776 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress