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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of mouse EO771 triple-negative breast cancer model with stemness inhibitors: salinomycin, SB-431542, JIB-04, napabucasin, and their quadruple combination against an untreated control

ABSTRACT: We conducted an in vivo study of stemness inhibitors using the EO771 triple-negative breast cancer mouse model. Ten days after subcutaneous injection of 1 million of EO771 cells into 8-12 week C57BL/6 female mice right flank, tumors reached around 100-200 mm³. Each treatment group (n=2-3 per group) received three doses of stemness inhibitors (every 3 days) in monotherapy (A - salinomycin, B - SB-431542, C - JIB-04, D - napabucasin) or combination therapy (ABCD). Control mice were left untreated. Tumors were harvested one day after the last treatment and subjected to bulk RNA-seq. This study aims to identify if treatment with stemness inhibitors affected the immune tumor microenvironment in this model.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER:

PROVIDER: E-MTAB-14915 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP170046

REPOSITORIES: biostudies-arrayexpress

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