Blood-based Prostate Cancer Transcriptomics: A Comparative Study Between South African and American Cohorts

ABSTRACT: Prostate cancer (PCa) is a major health problem worldwide with variable incidence, progression and outcomes depending on genetic, environmental and socio-economic factors. This study compares gene expression profiles in PCa patients from South Africa (RSA) and the United States (USA) using RNA sequencing in whole blood and pathway analyses. Whole blood samples were collected in Wren RNA stabilization tubes from RSA-PCa (n=6), RSA-controls (n=6), USA-PCa (n=7) and USA-Controls (n=11). RNA sequencing revealed 1,627 differentially expressed genes (DEGs) in RSA-PCa vs. RSA-controls, and 2,193 DEGs in USA-PCa vs. USA-Controls. Pathway analyses identified geographical region-specific variations; RSA-PCa had upregulated myeloid suppressor cell pathways and immunosuppressive markers while USA-PCa

INSTRUMENT(S): QiaCube MDx, Illumina NovaSeq 6000, None

ORGANISM(S): Homo sapiens

SUBMITTER: Srinivas Koduru 

PROVIDER: E-MTAB-14952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress