Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of cardiac hypertrophy

ABSTRACT: RNA sequencing (RNA-seq) on polyadenylated transcripts extracted from cardiomyocytes isolated from mice after 1 week of transverse aortic constriction (TAC) and in control mice (sham). 2-month-old male C57BL/6J mice were subjected under anesthesia to transverse aortic constriction for 1 week, then we performed RNA-seq on isolated cardiomyocytes

INSTRUMENT(S): AB SOLiD 5500

ORGANISM(S): Mus musculus

SUBMITTER: Roberto Papait 

PROVIDER: E-MTAB-1507 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy.

Papait Roberto R   Cattaneo Paola P   Kunderfranco Paolo P   Greco Carolina C   Carullo Pierluigi P   Guffanti Alessandro A   Viganò Valentina V   Stirparo Giuliano Giuseppe GG   Latronico Michael V G MV   Hasenfuss Gerd G   Chen Ju J   Condorelli Gianluigi G  

Proceedings of the National Academy of Sciences of the United States of America 20131127 50

Cardiac hypertrophy, initially an adaptive response of the myocardium to stress, can progress to heart failure. The epigenetic signature underlying this phenomenon is poorly understood. Here, we report on the genome-wide distribution of seven histone modifications in adult mouse cardiomyocytes subjected to a prohypertrophy stimulus in vivo. We found a set of promoters with an epigenetic pattern that distinguishes specific functional classes of genes regulated in hypertrophy and identified 9,207  ...[more]