Bulk RNA-seq of trigeminal ganglia from C57BL/6 (wild-type) and Trpv1KO mice with uni- and bilateral dry eye (uni- and bilateral extraorbital lacrimal gland excision model) versus sham-operated controls

ABSTRACT: The uni- and bilateral excision models allow comparison of the combined effects of ocular desiccation and neuroinflammation on trigeminal gene expression vs the isolated effects of neuroinflammation propagated from the other side. Also, the transient receptor potential vanilloid 1 (Trpv1)-deficient mice allow the assessment of the role of this channel. In the unilateral excision model, only the left trigeminal ganglia were analyzed, which were contralateral to the desiccated eyes (right eyes) secondary to excision of the right-side extraorbital lacrimal glands, as the left-side lacrimal glands were left untouched. Eight-week-old female mice of both strains were either operated on day 1 (either bilateral or unilateral -right-side- extraorbital lacrimal gland excision or sham surgery) and a

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Jeremías Galletti 

PROVIDER: E-MTAB-15193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress