Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Early gene expression after COVID-19 mRNA (BNT162b2) vaccination that is associated with spike-specific T cell responses

ABSTRACT: This study investigates the post-vaccination gene expression associated with T cell response and why humoral immunity does not inform cellular responses post-vaccination. The experiment is the transcriptional profiling of peripheral blood mononuclear cells (PBMCs) from 21/27 subjects collected at day 0 and day 1 post-vaccination (Dose 1).

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Justin Ooi 

PROVIDER: E-MTAB-15195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans.

Ooi Justin S G JSG   Hamis Noor Zayanah NZ   Tan Hwee Cheng HC   Yee Jia Xin JX   Chew Valerie S Y VSY   Lim Joey Ming Er JME   Ong Eugenia Z EZ   Chan Kuan Rong KR   Rivino Laura L   Low Jenny G JG   Ooi Eng Eong EE   Kalimuddin Shirin S  

Vaccine 20260324

Viral vaccine development has mostly relied on measuring neutralizing antibody responses to evaluate vaccine immunogenicity. Yet, a compelling body of evidence has now demonstrated that T cell immunity, an integral component of the adaptive immune response, also plays a critical role in controlling acute viral infection. T cell responses however, are not routinely measured in clinical trials to assess vaccine potency. If neutralizing antibody titers were indeed statistically associated with the  ...[more]

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