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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Early gene expression after YF17D vaccination that is associated with YF17D-specific T cell responses

ABSTRACT: This study investigates the post-vaccination gene expression associated with T cell response and why humoral immunity does not inform cellular responses post-vaccination. The experiment is the transcriptional profiling of peripheral blood mononuclear cells (PBMCs) from 12 subjects collected at day 0, day 4, day 7 and day 10 post yellow fever (YF) vaccination.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Justin Ooi

PROVIDER: E-MTAB-15199 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans.

Ooi Justin S G JSG Hamis Noor Zayanah NZ Tan Hwee Cheng HC Yee Jia Xin JX Chew Valerie S Y VSY Lim Joey Ming Er JME Ong Eugenia Z EZ Chan Kuan Rong KR Rivino Laura L Low Jenny G JG Ooi Eng Eong EE Kalimuddin Shirin S

Vaccine 20260324

Viral vaccine development has mostly relied on measuring neutralizing antibody responses to evaluate vaccine immunogenicity. Yet, a compelling body of evidence has now demonstrated that T cell immunity, an integral component of the adaptive immune response, also plays a critical role in controlling acute viral infection. T cell responses however, are not routinely measured in clinical trials to assess vaccine potency. If neutralizing antibody titers were indeed statistically associated with the ...[more]

PMID: 41880822

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