Prostate Cancer Initiating Cells Generation (EPT3 model)

ABSTRACT: Prostate cancer is the most frequently diagnosed malignancy in adult males. Though multiple factors have been implicated in prostate cancer progression, the trigger for initiation of malignancy is still a topic of debate. Advanced age is the single most significant risk factor for prostate cancer. Epidemiological and clinical studies indicate oxidative stress as one of the major aging-associated influences on prostate carcinogenesis. In this study, for the first time, we demonstrated the intrinsic association of ROS and IL6/STAT3 in prostate carcinogenesis. The high levels of ROS/IL6/STAT3 activation in this carcinogenesis model will benefit understanding of the mechanism of prostate cancer initiation and progression, as well as therapeutic development of anti-cancer drug targeting of the

ORGANISM(S): Homo sapiens

SUBMITTER: Kjell Petersen 

PROVIDER: E-MTAB-1521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress