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Visium Spatial data of Brain section from Parkinson Mouse Model based on inducible expression of human a-syn constructs

ABSTRACT: Visium Spatial dataset of 20-months and 3-months old transgenic mice. The model demonstrates α-syn oligomer spread and accumulation at synapses within specific forebrain and midbrain regions, including the SNpc, enabling the observation of α-syn oligomer propagation by including a human α-syn protein complementation system expressing α-syn fused to non-fluorescent Venus YFP halves (V1S and SV2), which can reconstitute to fluorescent Venus YFP (V1S/SV2) when α-syn oligomerization takes place. This dataset includes 3 animals per condition with 3-4 slices per animal. Processed count matrices, metadata and objects with filtered, clustered, and annotated data can be found on Zenodo: 1. 10.5281/zenodo.15274014 2. 10.5281/zenodo.14988055

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Jaehyun Lee

PROVIDER: E-MTAB-15216 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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