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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Are Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow

ABSTRACT: High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolbox of technologies to inform on bioactivity.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Claire Peart

PROVIDER: E-MTAB-15258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow.

Middleton Alistair M AM Reynolds Joe J Cable Sophie S Baltazar Maria Teresa MT Li Hequn H Bevan Samantha S Carmichael Paul L PL Dent Matthew Philip MP Hatherell Sarah S Houghton Jade J Kukic Predrag P Liddell Mark M Malcomber Sophie S Nicol Beate B Park Benjamin B Patel Hiral H Scott Sharon S Sparham Chris C Walker Paul P White Andrew A

Toxicological sciences : an official journal of the Society of Toxicology 20220801 1

An important question in toxicological risk assessment is whether non-animal new approach methodologies (NAMs) can be used to make safety decisions that are protective of human health, without being overly conservative. In this work, we propose a core NAM toolbox and workflow for conducting systemic safety assessments for adult consumers. We also present an approach for evaluating how protective and useful the toolbox and workflow are by benchmarking against historical safety decisions. The tool ...[more]

PMID: 35822611

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