Modelling group 3 medulloblastoma post radiotherapy

ABSTRACT: We have employed single cell RNA sequencing using the 10x Genomics platform to study the molecular mechanisms underlying resistance to treatment. In clinically relevant mouse models of G3 medulloblastoma, CT-guided fractionated radiotherapy was given to induce the clonal selection of radioresistant subpopulations. Comparison of recurrent and treatment naïve tumors revealed a prognostic gene expression signature reflective of radio-resistance.

INSTRUMENT(S): Illumina NovaSeq 6000, Chromium Controller

ORGANISM(S): Mus musculus

SUBMITTER: Pasqualino de Antonellis 

PROVIDER: E-MTAB-15292 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress