RNA-seq of different tissues from wild-type and C/EBPα ΔuORF mutant African turquoise killifish Nothobranchius furzeri

ABSTRACT: The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) regulates cell differentiation, proliferation, and function in various tissues, including the liver, adipose tissue, skin, lung, and hematopoietic system. Studies in rats, mice, humans, and chickens have shown that CEBPA mRNA undergoes alternative translation initiation, producing three C/EBPα protein isoforms. Two of these isoforms act as full-length transcription factors with N-terminal transactivation domains and a C-terminal dimerization and DNA-binding domain. The third isoform is an N-terminally truncated variant, translated from a downstream AUG codon. It competes with full-length isoforms for DNA binding, thereby antagonizing their activity. Expression of the truncated C/EBPα isoform depends on the initial trans

INSTRUMENT(S): Illumina NovaSeq X

ORGANISM(S): Nothobranchius furzeri

SUBMITTER: Eugene Berezikov 

PROVIDER: E-MTAB-15325 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress