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GeoMX spatial transcriptomics of diffuse pleural mesothelioma: impact of CDKN2A deletion

ABSTRACT: We compared GeoMX spatially resolved gene expression profiles of diffuse pleural mesothelioma (DPM) samples with or without somatic CDKN2A deletion. 5 CDKN2Adel and 4 WT DPM samples were analyzed. A total of 202 Areas Of Illumination (AOIs) were transcriptionally profiled, of which 140 Sarcomatoid-AOIs (S-AOIs) and 62 Epithelioid-AOIs (E-AOIs). Collectively, 97 AOIs belonged to WT DPM and 105 to CDKN2Adel DPMs.Profiling was performed using the GeoMx™Digital Spatial Profiler with Cancer Transcriptome Atlas panel.

INSTRUMENT(S): NextSeq 500, Nanostring GeoMx spatial profiler

ORGANISM(S): Homo sapiens

SUBMITTER: federica torricelli

PROVIDER: E-MTAB-15378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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