Radiotherapy-induced miR expression influences breast cancer recurrence formation.

ABSTRACT: The act of surgery strongly stimulated breast cancer cell growth in mice. Local irradiation of wounded breast efficiently prevented wounded-induced breast cancer cell growth. These modifications were linked to miR modulation both in human specimens and in the mouse model, in vivo. The most significantly IORT-induced miR was miR-223. miR-223 expression controlled EGF production and, eventually, cancer cell proliferation and survival.

ORGANISM(S): Homo sapiens

SUBMITTER: simona rossi 

PROVIDER: E-MTAB-1562 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress