ScRNA-seq of posterior brain organoid morphogen screen
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ABSTRACT: To pattern novel posterior brain regions, we used a multiplexed morphogen screen with a single-cell sequencing readout to test 48 concentrations and combinations of 10 morphogens involved in brain patterning. This screen revealed the emergence of regions harboring under-represented cell types, such as medulla glycinergic neurons and cerebellum glutamatergic cells, that expanded mesencephalon and rhombencephalon models.
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Nadezhda Azbukina
PROVIDER: E-MTAB-15660 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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