Transcriptional profiling of rats treated with VX-765 and Anakinra

ABSTRACT: Various studies showed a significant production/release of IL-1 beta following status epilepticus (SE) and during epileptogenesis. We studied the role of this cytokine in the epileptogenic process by blocking its production and downstream effects in vivo in a model of acquired epilepsy following SE induction. We used a pharmacological strategy consisting of the administration of two drugs, namely VX-765 and Anakinra, which selectively block the biosynthesis and the receptor type 1 of this cytokine, respectively.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Luca Beltrame 

PROVIDER: E-MTAB-1567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress