Nature versus nurture: Genetic background and media composition shape endothelial cell transcriptomes in vitro
Ontology highlight
ABSTRACT: This study performed transcriptional profiling of three independent human umbilical vein endothelial cell (HUVEC) lines derived from unique donors, each cultured in four different media formulations varying in basic composition, serum, and growth factor content. The aim was to evaluate the relative contributions of donor-specific genetic variation and culture conditions to endothelial transcriptomic profiles. Such an investigation is highly relevant, as primary endothelial cells (e.g., HUVECs) are widely used in basic research and drug development, yet published findings are often contradictory or difficult to reproduce.
ORGANISM(S): Homo sapiens
SUBMITTER: Flóra Dr. Demeter
PROVIDER: E-MTAB-15672 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
ACCESS DATA