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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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14 primary formalin fixated paraffin embedded (FFPE) PDAC tissue slices from 14 patients without pretreatment were analyzed using spatial transcriptomics

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) exhibits profound molecular heterogeneity and poor prognosis, necessitating novel tailored therapies. The basal and classical molecular subtypes of PDAC - driven by glycolysis versus lipid metabolism - have distinct prognostic implications. Spatial transcriptomics using FFPE tissue from 14 primary PDAC tumors was performed to spatially map PDAC molecular subtype heterogeneity. Our analysis resolved cancer cell signatures, deconvoluted intra-tumoral heterogeneity, and delineated a classical-to-basal trajectory.

INSTRUMENT(S): DNBSEQ-G400

ORGANISM(S): Homo sapiens

SUBMITTER: Alexandra Schmitt

PROVIDER: E-MTAB-15702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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