IGR_PhilippeVielh_THY_CGH

ABSTRACT: Although fine needle aspiration (FNA) cytology is helpful in determining whether thyroid nodules are benign or malignant, this distinction remains challenging in follicular neoplasms. Identification of genomic alterations in cytological specimens that distinguish between benign and malignant follicular tumors would have great clinical value. This study identified chromosomal imbalances in a set of 126 thyroid frozen follicular lesions characterized by histopathology, using aCGH, FISH, and DNA ploidy determination. An evaluation algorithm was developed based on a panel of three FISH experiments to better distinguish between follicular adenomas and carcinomas of the thyroid. This algorithm detects structural abnormalities that were observed in about half of the follicular thyroid carcinomas.

ORGANISM(S): Homo sapiens

SUBMITTER: Bastien JOB 

PROVIDER: E-MTAB-1575 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress